Midazolam impairs the retrieval of conditioned taste aversion via opioidergic transmission in mice

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• 作者：Yasunobu Yasoshima ; ^{yasosima@hus.osaka-u.ac.jp} ; Tsuyoshi Shimura
• 关键词：ANOVA ; analysis of variance ; CS ; conditioned stimulus ; CTA ; conditioned taste aversion ; MDZ ; midazolam ; NAL ; naloxone ; PBN ; parabrachial nucleus ; PBS ; phosphate buffered saline ; TR ; taste reaction ; US ; unconditioned stimulus
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：636
• 期：Complete
• 页码：64-69
• 全文大小：788 K
• 卷排序：636

文摘

Retrieval mechanisms of conditioned taste aversion (CTA) in mice were explored. Effects of systemic midazolam (MDZ) on CTA retrieval were tested. Systemic MDZ increased conditioned stimulus (CS) intake in conditioned mice. Systemic MDZ disrupted aversive orofacial reactions to the CS in conditioned mice. An opioid antagonist, naloxone, precluded midazolam’s effect on CTA retrieval.