Distribution of 5-HT_1B and 5-HT_1D receptors in the inner ear

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• 作者：Seong-Ki Ahn ; Carey D. Balaban
• 关键词：Inner ear ; Serotonin receptors ; Migrainous vertigo ; Vestibular ganglion ; Subarachnoid space
• 刊名：Brain Research
• 出版年：2010
• 出版时间：30 July 2010
• 年：2010
• 卷：1346
• 期：Complete
• 页码：92-101
• 全文大小：1544 K

文摘

Migraine and anxiety disorders are frequently co-morbid with balance disorders. This study examined the relative distribution of subtypes of serotonin (5-HT) receptor in the inner ear of monkeys and rats. Most vestibular ganglion cells were immunoreactive for 5-HT_1B and 5-HT_1D receptors in macaques and rats. In the inner ear, 5-HT_1B and 5-HT_1D receptor immunopositivity was associated with endothelial cells of the vestibular ganglion, spiral ganglion, vestibulocochlear nerve, spiral ligament and stria vascularis. It was noteworthy that 5-HT_1B and 5-HT_1D receptors are expressed in parallel sites in peripheral vestibular and trigeminal systems, which may be a factor underlying the efficacy of triptans in treating migraine and migrainous vertigo. Because the vestibular ganglion and trigeminal ganglion are both within the subarachnoid space, an interaction between 5-HT_1B and TRPV1 receptors on blood vessel and ganglion cells may also contribute to the vasospasm and the comorbid headache, dizziness, nausea and vomiting that accompany subarachnoid hemorrhage.