Effects of acetazolamide on epileptic apnea in migrating partial seizures in infancy

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• 作者：Kaori  ; Irahara^a ; Yoshiaki  ; Saito^a ;   ; ^{saitoyo@ncnp.go.jp} ; Kenji  ; Sugai^a ; Eiji  ; Nakagawa^a ; Takashi  ; Saito^a ; Hirofumi  ; Komaki^a ; Shin  ; Nabatame^a ; Yuu  ; Kaneko^b ; Mamiko  ; Hotate^c ; Masayuki  ; Sasaki^a
• 关键词：Apnea ; Malignant migrating partial seizures ; Temporal lobe ; Acetazolamide
• 刊名：Epilepsy Research
• 出版年：2011
• 出版时间：September 2011
• 年：2011
• 卷：96
• 期：1-2
• 页码：185-189
• 全文大小：582 K

文摘

Summary

We report two cases of migrating partial seizures in infancy complicated with intractable epileptic apnea with severe desaturation. Ictal electroencephalography revealed migrating foci of epileptiform discharges, which spread to bilateral temporal areas resulting in the onset of apnea. Magnetoencephalography detected dipole sources at bilateral perisylvian areas. Single photon emission tomography revealed a significant ictal change in perfusion at bilateral anterior temporal lobes in one patient. Addition of acetazolamide to the regimen resulted in complete disappearance of epileptic seizures.