A case of malignant migrating partial seizures in infancy as a continuum of infantile epileptic encephalopathy

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• 作者：Eun Hye Lee ; Mi-Sun Yum ; Min-Hee Jeong ; Kyung Yeon Lee ; Tae-Sung Ko
• 关键词：Migrating partial seizure ; Epileptic encephalopathy ; Infantile spasms
• 刊名：Brain and Development
• 出版年：2012
• 出版时间：October, 2012
• 年：2012
• 卷：34
• 期：9
• 页码：768-772
• 全文大小：2089 K

文摘

The syndrome of malignant migrating partial seizures in infancy (MMPSI) is characterized by onset before the age of 6 months, nearly continuous electrographic seizures involving multiple independent areas of onset in both hemispheres, and poor developmental outcome. This report presents a case involving a patient with MMPSI, who later developed West syndrome. At the age of 2 months old, he showed multifocal partial seizures, which were refractory to antiepileptic drugs. His electroencephalogram (EEG) revealed characteristic migrating multifocal epileptiform activities and neuroimaging finding was normal. The focal seizures were refractory to antiepileptic drugs and ketogenic diet. When he was 9 months old, epilepic spasms were observed with hypsarrhythmia on EEG. He also showed severe developmental delay. MMPSI may be a continuum of infantile epileptic encephalpathy and could evolve to West syndrome.