Integrin-mediated cell migration is blocked by inhibitors of human neuraminidase
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- 作者：Feng Jia ; Md. Amran Howlader ; Christopher W. Cairo ; ccairo@ualberta.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：CER ; ceramide ; C9-4HMT-DANA ; 9-[4-hydroxymethyl-[1 ; 2 ; 3]triazol-1-yl]-2 ; 3-didehydro-N-acetyl-neuraminic acid ; DANA ; 2 ; 3-didehydro-N-acetyl-neuraminic acid ; ECM ; extracellular matrix ; FN ; fibronectin ; hNeu ; human neuraminidase enzyme ; HPTLC ; high performance thin layer chromatography ; LN ; laminin ; 4MU-NANA ; 4-methylumbelliferyl-N-acetyl-neuraminic acid ; pfNeu ; C. perfringens neuraminidase ; SPT ; single particle tracking ; TIRF ; total internal reflection fluorescence
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：1861
- 期：9
- 页码：1170-1179
- 全文大小：1252 K
文摘
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Human Neu3 and Neu4 alter cell motility in cultured cells (HeLa and A549).
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Recombinant Neu3 can be used to selectively reduce sialylated-GSL.
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Inhibitors of human Neu enzymes inhibit cell migration.
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Isoform-selective Neu4 inhibitors are more potent than non-specific inhibitors.