Overexpression of the 14-3-3gamma protein in embryonic mice results in neuronal migration delay in the developing cerebral cortex
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- 作者：Brett Cornell ; Tomoka Wachi ; Vladimir Zhukarev ; Kazuhito Toyo-oka ; ktoyooka@drexelmed.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：14-3-3 ; 14-3-3gamma ; Neuronal migration ; Neurodevelopmental defects ; In utero electroporation ; 7q11.23 duplication
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：15 August 2016
- 年：2016
- 卷：628
- 期：Complete
- 页码：40-46
- 全文大小：2970 K
文摘
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In utero overexpression of the 14-3-3γ protein disrupts cortical neuronal migration.
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Neurons overexpressing 14-3-3γ do not reach target in the cortical plate by P3.
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Overexpressing neurons do reach their target by P15, indicating migration delay.