The frailty syndrome and mortality among very old patients with symptomatic severe aortic stenosis under different treatments

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• 作者：Carlos Rodr&iacute ; guez-Pascual^a ; ^b ; ^{CRodriguezpascual@lincoln.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Emilio Paredes-Galá ; n^c ; Ana Isabel Ferrero-Mart&iacute ; nez^a ; José ; Antonio Baz-Alonso^d ; Dar&iacute ; o Durá ; n-Muñ ; oz^e ; Eva Gonzá ; lez-Babarro^f ; Marcelo Sanmart&iacute ; n^g ; Teresa Parajes^a ; Ivett Torres-Torres^a ; Miguel Piñ ; ó ; n-Esteban^e ; Francisco Calvo-Iglesias^c ; Maria Teresa Olcoz-Chiva^a ; Fernando Rodr&iacute ; guez-Artalejo^h
• 关键词：ADL ; Activities of Daily Living ; CGA ; Comprehensive Geriatric Assessment ; CHS ; Cardiovascular Health Study ; IADL ; Instrumental Activities of Daily Living ; NYHA ; New York Heart Association ; MMSE ; Mini-Mental State Examination ; NTproBNP ; N-terminal pro BNP peptide ; PASE ; Physical Activity Scale for the Elderly ; SAS ; Severe Aortic Stenosis ; SAVR ; Surgical Aortic Valve Replacement ; STS ; Society of Thoracic Surgeons ; TAVR ; Transcatheter Aortic Valve Replacement
• 刊名：International Journal of Cardiology
• 出版年：2016
• 出版时间：1 December 2016
• 年：2016
• 卷：224
• 期：Complete
• 页码：125-131
• 全文大小：448 K

文摘

The role of frailty as a prognostic factor in non-selected patients with symptomatic severe aortic stenosis (SAS) is still uncertain. This study aims to examine the association between the frailty syndrome and mortality among very old patients with symptomatic SAS, and to assess whether the association varies with the type of SAS treatment.

Methods and results

Prospective study of 606 patients aged ≥ 75 years with symptomatic SAS, recruited from February 2010 to January 2015, who were followed up through June 2015. At baseline, frailty was defined as having at least three of the following five criteria: muscle weakness, slow gait speed, low physical activity, exhaustion, and unintentional weight loss. Statistical analyses were performed with multivariate Cox regression. At baseline, 49.3% patients were frail. During a mean follow-up of 98 weeks, 35.3% of patients died. The hazard ratio (95% confidence interval) of mortality among frail versus non-frail patients was 1.83 (1.33–2.51). The corresponding results were 1.58 (1.09–2.28) among patients under medical treatment, 3.06 (1.25–7.50) in those with transcatheter aortic valve replacement, and 1.97 (0.83–4.67) in those with surgical aortic valve replacement, p for interaction = 0.21. When the frailty criteria were considered separately, mortality was also higher among patients with slow gait speed [1.52 (1.05–2.19)] or low physical activity [1.35 (1.00–1.85)].

Conclusions

Frailty is associated with increased mortality among patients with symptomatic SAS, and this association does not vary with the type of SAS treatment. Future studies evaluating the benefits of different treatments in SAS patients should account for baseline frailty.