Convenient preparation of unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles promoted by Dess–Martin reagent

详细信息    查看全文

• 作者：Cristian Dobrotă ; Codruţ ; a C. Paraschivescu ; Ioana Dumitru ; Mihaela Matache ; Ion Baciu ; Lavinia L. Ruţ ; ă
• 关键词：1 ; 3 ; 4-Oxadiazoles ; Oxidative cyclization ; Dess– ; Martin periodinane ; Heterocycles
• 刊名：Tetrahedron Letters
• 出版年：2009
• 出版时间：29 April 2009
• 年：2009
• 卷：50
• 期：17
• 页码：1886-1888
• 全文大小：186 K

文摘

2,5-Disubstituted 1,3,4-oxadiazoles have been conveniently prepared by oxidative cyclization of N-acyl-N′-aryliden-hydrazines promoted by an excess of Dess–Martin periodinane under mild conditions (23 examples, up to 92 % isolated yields).