Extended release of vitamins from magnetite loaded polyanionic polymeric beads

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• 作者：Maria Sonmez ; Cristina Verisan ; Georgeta Voicu ; Denisa Ficai ; Anton Ficai ; Alexandra Elena Oprea ; ^{elena_oprea_93@yahoo.co.uk" class="auth_mail" title="E-mail the corresponding author} ; Mihaela Vlad ; Ecaterina Andronescu
• 关键词：Magnetite&ndash ; vitamins ; Folic acid ; Ascorbic acid ; Polymeric beads
• 刊名：International Journal of Pharmaceutics
• 出版年：2016
• 出版时间：30 August 2016
• 年：2016
• 卷：510
• 期：2
• 页码：457-464
• 全文大小：2559 K

文摘

Here we explore a novel approach of increasing the release duration of folic and ascorbic acid from magnetite entrapped into calcium–alginate beads. Synthesis and characterization of magnetite-vitamins complexes are reported. The magnetite–vitamins complexes were characterized by FT-IR, XRD, SEM, BET and DTA-TG. Also calcium–alginate magnetic beads were prepared by dripping a mixture of sodium alginate with magnetite-vitamins complexes into calcium chloride solution. Extended release profile of the two experimental models was evaluated and quantified by UV–vis.