Investigation of the metabolites of the HIF stabilizer FG-4592 (roxadustat) in five different in vitro models and in a human doping control sample using high resolution mass spectrometry

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• 作者：Annelie Hansson^a ; ^{Annelie.Hansson@farmkemi.uu.se} ; Mario Thevis^b ; ^{Thevis@dshs-koeln.de} ; Holly Cox^c ; ^{hcox@smrtl.org} ; Geoff Miller^c ; ^{gmiller@smrtl.org} ; Daniel Eichner^c ; ^de@smrtl.org ; Ulf Bondesson^a ; ^d ; ^{Ulf.Bondesson@sva.se} ; Mikael Hedeland^a ; ^d ; ^{Mikael.Hedeland@sva.se}
• 关键词：FG-4592 ; Drug metabolism ; High resolution mass spectrometry
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：134
• 期：Complete
• 页码：228-236
• 全文大小：1176 K
• 卷排序：134

文摘

Metabolites from the HIF stabilizer FG-4592 were investigated. Five in vitro methods and a human doping control sample were used as models. Twelve different metabolites were detected using UHPLC-QTOF-MS. Three of the in vitro models had one metabolite in common.