R-spondin 2 facilitates differentiation of proliferating chondrocytes into hypertrophic chondrocytes by enhancing Wnt/β-catenin signaling in endochondral ossification
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- 作者：Yasuhiko Takegamia ; b ; Bisei Ohkawaraa ; Mikako Itoa ; Akio Masudaa ; Hiroaki Nakashimab ; 1 ; Naoki Ishigurob ; Kinji Ohnoa ; ohnok@med.nagoya-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：R-spondin2 (Rspo2) ; Endochondral ossification ; Wnt/β-catenin signaling ; Collagen type II ; Chondrocytes
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：22 April 2016
- 年：2016
- 卷：473
- 期：1
- 页码：255-264
- 全文大小：1837 K
文摘
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Rspo2 is a secreted activator of Wnt, and its knockout shows extended proliferating chondrocytes in endochondral ossification.
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In proliferating chondrocytes of Rspo2-knockout mice, Sox9 and collagen type 2 are increased and β-catenin is decreased.
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Rspo2 and its receptor Lgr5, as well as Sox9 and collagen type 2, are expressed in differentiating ATDC5 chondrogenic cells.
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In ATDC5 cells, Rspo2 decreases expressions of Sox9, collagen type 2, and aggrecan through Wnt/β-catenin signaling.
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We propose that Rspo2 activates Wnt/β-catenin to facilitate chondrocyte differentiation in endochondral ossification.