Lysosome-associated membrane proteins-1 and -2 (LAMP-1 and LAMP-2) assemble via distinct modes
详细信息 查看全文
- 作者：Kazue Terasawaa ; 1 ; Yuri Tomabechib ; 1 ; Mariko Ikedab ; Haruhiko Eharab ; Mutsuko Kukimoto-Niinob ; Motoaki Wakiyamab ; Katarzyna A. Podyma-Inouea ; Anupama R. Rajapakshea ; Tetsuro Watabea ; Mikako Shirouzub ; Miki Hara-Yokoyamaa ; m.yokoyama.bch@tmd.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：LAMP-1 ; LAMP-2 ; β-prism fold ; Protein assembly ; Crystallographic analysis
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：21 October 2016
- 年：2016
- 卷：479
- 期：3
- 页码：489-495
- 全文大小：1424 K
文摘
- •
The subdomains of LAMP-1 and LAMP-2 adopt the unique β-prism fold.
- •
The N-domain of LAMP-1 is necessary for the assembly of LAMPs.
- •
The C-domain of LAMP-2 represses the assembly of LAMPs.
- •
The assembly modes of LAMP-1 and LAMP-2 are different.