RNA helicase Belle (DDX3) is essential for male germline stem cell maintenance and division in Drosophila
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- 作者：Alexei A. Kotov ; Oxana M. Olenkina ; Mikhail V. Kibanov ; Ludmila V. Olenina ; olenina_ludmila@mail.ru" class="auth_mail" title="E-mail the corresponding author
- 关键词：PGCs ; primordial germ cells ; GSCs ; germline stem cells ; SCOS ; Sertoli Cell-Only Syndrome ; CySCs ; somatic cyst stem cells
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：1863
- 期：6
- 页码：1093-1105
- 全文大小：4135 K
文摘
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Belle is required intrinsically for mitosis and survival of germline stem cells.
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Somatic hub and cyst cells are maintained in bel mutants.
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Early germ cells are lost through cell death in bel mutants.
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Belle functions upstream of Cyclin B for maintenance of male germline stem cells.