Neuroprotective efficacy of poly-arginine R18 and NA-1 (TAT-NR2B9c) peptides following transient middle cerebral artery occlusion in the rat

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• 作者：Diego Milani^a ; ^b ; ^d ; ^{diemilani@gmail.com} ; ^{diego.milani1@my.nd.edu.au} ; Jane L. Cross^b ; ^c ; ^d ; Ryan S. Anderton^a ; ^b ; David J. Blacker^b ; ^c ; ^e ; Neville W. Knuckey^b ; ^c ; ^d ; Bruno P. Meloni^b ; ^c ; ^d
• 关键词：Transient middle cerebral artery occlusion ; Neuroprotection ; Stroke ; R18 ; NA-1 (TAT-NR2B9c) ; Poly-arginine peptides
• 刊名：Neuroscience Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：114
• 期：Complete
• 页码：9-15
• 全文大小：1497 K
• 卷排序：114

文摘

R18 peptide reduces infarct volume following transient MCAO in the rat. R18 is neuroprotective when administered 60 min after the onset of MCAO. R18 reduces cerebral edema and improves functional outcomes. R18 appears more effective than the highly characterized NA-1 peptide. R18 is a potential neuroprotective treatment for stroke.