MMP-9 and MMP-2 Contribute to Neuronal Cell Death in iPSC Models of Frontotemporal Dementia with MAPT Mutations
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- 作者：Md Helal U. Biswas1 ; Sandra Almeida1 ; Rodrigo Lopez-Gonzalez1 ; Wenjie Mao2 ; Zhijun Zhang1 ; 5 ; Anna Karydas3 ; Michael D. Geschwind3 ; Jacek Biernat4 ; Eva-Maria Mandelkow4 ; Kensuke Futai2 ; Bruce L. Miller3 ; Fen-Biao Gao1 ; fen-biao.gao@umassmed.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：frontotemporal dementia ; iPSCs ; MMP-2 ; MMP-9 ; neuronal survival ; neurons ; tau
- 刊名：Stem Cell Reports
- 出版年：2016
- 出版时间：13 September 2016
- 年：2016
- 卷：7
- 期：3
- 页码：316-324
- 全文大小：1856 K
文摘
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New iPSC lines with MAPT p.A152T and IVS10+16 mutations are generated
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MMP-2 and MMP-9 production is elevated in human neurons with MAPT mutations
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Elevated MMP-2 and MMP-9 contribute to stress-induced neuronal cell death
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Mutant tau increases ERK phosphorylation that activates MMP-9 expression