Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells
详细信息 查看全文
- 作者：David L. Schonberg1 ; Tyler E. Miller1 ; Qiulian Wu1 ; William A. Flavahan1 ; Nupur K. Das2 ; James S. Hale2 ; Christopher G. Hubert1 ; Stephen C. Mack1 ; Awad M. Jarrar2 ; Robert T. Karl3 ; Ann Mari Rosager4 ; Anne M. Nixon7 ; Paul J. Tesar3 ; Petra Hamerlik5 ; Bjarne W. Kristensen4 ; Craig Horbinski6 ; James R. Connor7 ; Paul L. Fox2 ; Justin D. Lathia2 ; Jeremy N. Rich1 ; richj@ccf.org" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cancer Cell
- 出版年：2015
- 出版时间：12 October 2015
- 年：2015
- 卷：28
- 期：4
- 页码：441-455
- 全文大小：6398 K
文摘
- •
Iron uptake and dependence are enhanced in cancer stem-like cells (CSCs)
- •
CSCs use tumor-specific epigenetic programs to upregulate transferrin
- •
Transferrin receptor and ferritin are necessary for tumorigenesis
- •
Gene expression profiling reveals ferritin-dependent regulation of FoxM1 signaling