Epigenomics-Based Identification of Major Cell Identity Regulators within Heterogeneous Cell Populations

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• 作者：Rizwan Rehimi¹ ; Milos Nikolic¹ ; Sara Cruz-Molina¹ ; Christina Tebartz¹ ; Peter Frommolt² ; Esther Mahabir¹ ; Mathieu Clé ; ment-Ziza¹ ; ² ; ^{mathieu.clement-ziza@uni-koeln.de} ; Alvaro Rada-Iglesias¹ ; ² ; ³ ; ^{aradaigl@uni-koeln.de}
• 关键词：heterogeneity ; patterning ; epigenomic ; dorsoventral ; spinal neutral tube ; gene expression ; H3K27me3
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：13 December 2016
• 年：2016
• 卷：17
• 期：11
• 页码：3062-3076
• 全文大小：5174 K
• 卷排序：17

文摘

A simple epigenomic strategy to functionally dissect cellular heterogeneity is developed Patterning regulators are identified with high sensitivity and precision ZNF488 acts as a dorsoventral patterning regulator in the chicken spinal tube This strategy is applicable to a broad range of tissues and organisms