Development of PLGA-PEG encapsulated miltefosine based drug delivery system against visceral leishmaniasis
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- 作者：Rishikesh Kumara ; Ganesh Chandra Sahooa ; ; Krishna Pandeyb ; ; V.N.R. Dasb ; Roshan K. Topnob ; Md Yousuf Ansaric ; Sindhuprava Ranaa ; Pradeep Dasd
- 关键词：Miltefosine ; Transmission electron microscope ; Nanoscale ; Amastigotes ; Amphoterecin B
- 刊名：Materials Science & Engineering C
- 出版年：2016
- 出版时间：1 February 2016
- 年：2016
- 卷：59
- 期：Complete
- 页码：748-753
- 全文大小：612 K
文摘
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Synthesis of PLGA-PEG encapsulated miltefosine nanoparticles has been done.
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An IC50 value of PPEM (0.1 ug/ml), miltefosine (0.2 μg/ml) and AmpB (1 μg/ml) were observed two fold better efficacies.
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Inhibition of amastigotes of PPEM (23.21 ± 23) was significantly more than miltefosine (89.22 ± 52.7) and AmpB (94.12 ± 55.1).