Hemolytic potential of miltefosine is dependent on cell concentration: Implications for in vitro cell cytotoxicity assays and pharmacokinetic data
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- 作者：Lais Alonso ; Antonio Alonso ; alonso@ufg.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Miltefosine ; Hemolysis ; Membrane ; Pharmacokinetics
- 刊名：Biochimica et Biophysica Acta (BBA)-Biomembranes
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：1858
- 期：6
- 页码：1160-1164
- 全文大小：533 K
文摘
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The hemolytic potential of miltefosine is hematocrit dependent.
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IC50values in cytotoxicity assays are dependent on cell concentration.
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In erythrocyte membranes, 50% hemolysis was observed for 111 mM miltefosine.