Pharmacokinetics and bioavailability assessment of Miltefosine in rats using high performance liquid chromatography tandem mass spectrometry
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- 作者：Guru R. Valicherlaa ; d ; 1 ; Priyanka Tripathib ; d ; 1 ; Sandeep K. Singha ; Anees A. Syeda ; Mohammed Riyazuddina ; Athar Husaina ; Deep Javiac ; Kishan S. Italiyac ; Prabhat R. Mishrab ; d ; Jiaur R. Gayena ; d ; jr.gayen@cdri.res.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Miltefosine ; Leishmaniasis ; LC&ndash ; MS/MS ; Pharmacokinetics ; Bioavailability
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：15 September 2016
- 年：2016
- 卷：1031
- 期：Complete
- 页码：123-130
- 全文大小：1108 K
文摘
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LC–MS/MS method of Miltefosine (MFS) was developed for the first time in rat plasma.
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The method was validated and stability studies were performed.
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Lower limit of quantification of MFS for the LC–MS/MS method was 1 ng/mL.
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Absolute bioavailability of MFS was 60.33 ± 2.32% in rats.
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MFS has slow absorption, long half-life and high apparent volume of distribution.