Biosynthesis and Regulation of Active Compounds in Medicinal Model Plant Salvia miltiorrhiza

详细信息    查看全文

• 作者：Zhi-chao Xu^a ; Ai-jia Ji^a ; Xin Zhang^a ; Jing-yuan Song^a ; ^{jysong@implad.ac.cn" class="auth_mail" title="E-mail the corresponding author} ; Shi-lin Chen^a ; ^b
• 关键词：omics ; phenolic acids ; Salvia miltiorrhiza ; synthetic biology ; tanshinones ; transcription factors
• 刊名：Chinese Herbal Medicines
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：8
• 期：1
• 页码：3-11
• 全文大小：1222 K

文摘

Natural products from plant secondary metabolits are a major source of clinical drugs and industrial chemicals. Salvia miltiorrhiza is one of the most important plants in traditional Chinese medicine. Its dried roots and rhizomes are highly valued for use in the treatment of vascular diseases and for their anti-oxidative activities. Furthermore, S. miltiorrhiza is described as a medicinal model plant mainly due to its biosynthesis of active compounds. Here, we reviewed the research on S. miltiorrhiza in genomics, transcriptomics, biosynthesis of tanshinones and phenolic acids, biotic and abiotic elicitors, and regulation of transcription factors. This will provide a solid foundation for new breeding and synthetic biology approaches to produce and study natural products.