Drosophila expressing human SOD1 successfully recapitulates mitochondrial phenotypic features of familial amyotrophic lateral sclerosis
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- 作者：Xavier Gallart-Palaua ; b ; c ; xavgallart@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Chee-Hoe Nge ; f ; Joan Riberaa ; b ; Siu Kwan Szec ; Kah-Leong Limd ; e ; f
- 关键词：FALS ; SOD1G93A ; Mitochondria ; Drosophila
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：15 June 2016
- 年：2016
- 卷：624
- 期：Complete
- 页码：47-52
- 全文大小：1650 K
文摘
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Expression of SOD1G93A in Drosophila thoracic muscles causes FALS phenotype.
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24B-GAL4-SOD1G93A flies show impaired motor behavior and decreased lifespan.
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24B-GAL4-SOD1G93A flies successful mimic mitochondrial dysfunction in FALS.
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24B-GAL4-SOD1G93A represents novel therapeutic opportunities in FALS.