IRF8 Transcription-Factor-Dependent Classical Dendritic Cells Are Essential for Intestinal T Cell Homeostasis
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- 作者：Katarzyna M. Luda1 ; Thorsten Joeris2 ; Emma K. Persson1 ; 9 ; Aymeric Rivollier2 ; Mimoza Demiri1 ; Katarzyna M. Sitnik2 ; Lieneke Pool2 ; Jacob B. Holm3 ; Felipe Melo-Gonzalez4 ; 5 ; 6 ; Lisa Richter7 ; Bart N. Lambrecht8 ; Karsten Kristiansen3 ; Mark A. Travis4 ; 5 ; 6 ; Marcus Svensson-Frej1 ; Knut Kotarsky1 ; William W. Agace1 ; 2 ; william.agace@med.lu.se" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2016
- 出版时间：19 April 2016
- 年：2016
- 卷：44
- 期：4
- 页码：860-874
- 全文大小：4020 K
文摘
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SI T cell numbers are reduced in the absence of IRF8-dependent DCs
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CD103+CD11b− migratory DCs are required for optimal generation of SI homing T cells
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β8 integrin expression by CD103+CD11b− DCs promotes SI CD4+CD8αα+ IEL generation
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IRF8-dependent DCs play a key role in intestinal Th1 cell differentiation