MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes
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- 作者：Syed Arif Abdul Rehman1 ; 3 ; Yosua Adi Kristariyanto1 ; 3 ; Soo-Youn Choi1 ; 3 ; Pedro Junior Nkosi1 ; Simone Weidlich1 ; Karim Labib1 ; Kay Hofmann2 ; Yogesh Kulathu1 ; ykulathu@dundee.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：7 July 2016
- 年：2016
- 卷：63
- 期：1
- 页码：146-155
- 全文大小：3560 K
文摘
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MINDY is a new family of DUBs consisting of FAM63A, FAM63B, FAM188A, and FAM188B
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MINDY DUBs are highly selective at cleaving K48-linked polyubiquitin
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Catalytic domain of MINDY-1 adopts a distinct fold with no homology to any known DUB
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Human MINDY-1 trims ubiquitin chains from the distal end