Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery
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- 作者：Alan Merk1 ; 3 ; Alberto Bartesaghi1 ; 3 ; Soojay Banerjee1 ; 3 ; Veronica Falconieri1 ; Prashant Rao1 ; Mindy I. Davis2 ; Rajan Pragani2 ; Matthew B. Boxer2 ; Lesley A. Earl1 ; Jacqueline L.S. Milne1 ; Sriram Subramaniam1 ; ss1@nih.gov" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：16 June 2016
- 年：2016
- 卷：165
- 期：7
- 页码：1698-1707
- 全文大小：4743 K
文摘
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Near-atomic-resolution structure of isocitrate dehydrogenase, a < 100 kDa enzyme
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1.8 Å resolution cryo-EM map of 334 kDa glutamate dehydrogenase
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2.8 Å resolution cryo-EM map of lactate dehydrogenase, a 145 kDa protein
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Localization of small-molecule inhibitors bound to metabolic protein complexes