Müller cell metabolic chaos during retinal degeneration
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- 作者：Rebecca L. Pfeiffera ; b ; R.Pfeiffer@utah.edu" class="auth_mail" title="E-mail the corresponding author ; Robert E. Marca ; b ; Mineo Kondoc ; Hiroko Terasakid ; Bryan W. Jonesa ; b
- 关键词：Retinal degeneration ; Mü ; ller cell ; Retinal remodeling ; Retina ; Computational molecular phenotyping (CMP) ; Retinitis pigmentosa (RP)
- 刊名：Experimental Eye Research
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：150
- 期：Complete
- 页码：62-70
- 全文大小：3473 K
文摘
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Müller cell metabolism is evaluated using Computational Molecular Phenotyping in degenerating retina.
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Müller cells from degenerating retinas demonstrate high levels of variability in neighboring cells.
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Mathematical clustering is incapable of grouping all Müller variants from degenerating retinas into a single class.
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Variability in neighboring cells indicates Müller cells have the capacity to individually respond to retinal stress.