Cognitive Adaptation under Stress: A Case for the Mineralocorticoid Receptor

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• 作者：Susanne Vogel¹ ; Guillé ; n Ferná ; ndez² ; Marian Joë ; ls³ ; Lars Schwabe¹ ; ^{lars.schwabe@uni-hamburg.de" class="auth_mail" title="E-mail the corresponding author}
• 关键词：stress ; cortisol ; mineralocorticoid receptor ; adaptation ; cognition ; memory
• 刊名：Trends in Cognitive Sciences
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：20
• 期：3
• 页码：192-203
• 全文大小：2060 K

文摘

Corticosteroid hormones, released during stressful encounters, have profound and far-reaching effects on cognition. They are often thought to accomplish these effects primarily via glucocorticoid receptors (GR), but recent findings from rodent and human studies argue for an additional, critical role of the mineralocorticoid receptor (MR) in cognitive changes in response to stress. We propose that the MR initiates rapid changes in the recruitment of specific neural systems, inducing a shift towards cognitively less-demanding processing and allowing a quick and adequate response to the situation. In combination with slower and longer-lasting actions mediated by GR, this shift leads to optimal coping with the ongoing stressful event.