Inflammation influences steroid hormone receptors targeted by progestins in endometrial stromal cells from women with endometriosis
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- 作者：Giovanni Grandia ; Michael D. Muellerb ; c ; Andrea Papadiab ; Vida Kocbekc ; Nick A. Bersingerb ; c ; Felice Petragliad ; Angelo Cagnaccia ; Brett McKinnonb ; c ; brett.mckinnon@dkf.unibe.ch" class="auth_mail" title="E-mail the corresponding author
- 关键词：Endometriosis ; Progestin ; Inflammation ; Progesterone receptor ; Glucocorticoid receptor ; Mineralocorticoid receptor ; Membrane progesterone receptor ; Androgen receptor
- 刊名：Journal of Reproductive Immunology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：117
- 期：Complete
- 页码：30-38
- 全文大小：2062 K
文摘
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Inflammation influences progestins targets of endometrial cells refluxed in ectopic sites.
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Inflammatory cytokines, like TNFα and IL-1β, can reduce the expression of progesterone receptors.
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The same cytokines can increase the expression of glucocorticoid receptors.
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These findings could contribute to the progesterone resistance observed in endometriosis.
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This findings may suggest the design of more targeted therapies with an effective local activity.