Effect of Renshen polysaccharides on oxidative injury in kidney IR rabbits
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- 作者：Zhangshun Liu ; Chao Li ; Qin Zhang ; Minfang Tao
- 关键词：Renshen polysaccharides ; Antioxidant ; Gas chromatography&ndash ; mass spectrometry ; Kidney ; Ischemia ; Chemical analysis
- 刊名：Carbohydrate Polymers
- 出版年：2012
- 出版时间：1 October, 2012
- 年：2012
- 卷：90
- 期：2
- 页码：773-777
- 全文大小：226 K
文摘
There is increasing evidence to suggest that reactive oxygen metabolites (ROMs) play a role in the pathogenesis of ischemia/reperfusion (I/R) injury in the kidney. This study was designed to determine the possible protective effect of Renshen polysaccharides (RSP) on renal ischemia/reperfusion (I/R) injury. Results showed that the polysaccharides of Renshen consisted mainly of glucose (29.21 % ), mannose (6.54 % ), rhamnose (4.34 % ), arabose (6.92 % ), galactose (18.41 % ). In addition, kidney lipid peroxidation level in IR rabbits were markedly increased, whereas antioxidant enzymes activities were significantly decreased. Renshen polysaccharides pre-treatment could decrease oxidative injury in kidney of IR rabbits.