Prokineticin 2 Plays a Pivotal Role in Psoriasis

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• 作者：Xiaoqin He^a ; ¹ ; Chuanbin Shen^a ; ^b ; ¹ ; Qiumin Lu^a ; ¹ ; Jiong Li^c ; Yuquan Wei^c ; Li He^d ; Ruizhen Bai^e ; Jie Zheng^f ; Ning Luan^g ; Zhiye Zhang^a ; Mingqiang Rong^a ; ^{rongmingqiang@mail.kiz.ac.cn} ; Ren Lai^a ; ^{rlai@mail.kiz.ac.cn}
• 关键词：Prokineticin2 ; Psoriasis ; Interleukin-1 ; Angiogenesis ; Inflammation ; Cell proliferation
• 刊名：EBioMedicine
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：13
• 期：Complete
• 页码：248-261
• 全文大小：3806 K
• 卷排序：13

文摘

High level of PK2 is found in psoriasis but not in other autoimmunity diseases. Bacterial products induce PK2 over-expression to promote IL-1 signal. IL-1 induces PK2 secretion to create a PK2-IL-1 circle to perpetuate symptoms. PK2 is a central player in psoriasis and may be a psoriasis-specific target.Psoriasis is a common autoimmune disease whose pathogenesis remains poorly understood. We found that PK2 was highly expressed in psoriasis but not in other autoimmune diseases. To investigate the role of PK2 in psoriasis, the effect of PK2 on keratinocyte proliferation, inflammation and angiogenesis were analyzed. PK2 expression mediated by virus in psoriasis was applied. The results demonstrated that PK2 promoted psoriasis development. PK2 over-expression in mouse model aggravates psoriasis while knock-down of PK2 improves the disease. PK2 plays a pivotal role in psoriasis.