cRGD-functionalized mPEG-PLGA-PLL nanoparticles for imaging and therapy of breast cancer

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• 作者：Peifeng Liu ; Liubin Qin ; Qi Wang ; Ying Sun ; Mingjie Zhu ; Ming Shen ; Yourong Duan
• 关键词：Nanoparticles ; Targeted delivery ; Breast cancer ; Tumor imaging ; Tumor therapy
• 刊名：Biomaterials
• 出版年：2012
• 出版时间：October, 2012
• 年：2012
• 卷：33
• 期：28
• 页码：6739-6747
• 全文大小：1659 K

文摘

Cyclic peptide (arginine-glycine-aspartic-glutamic-valine acid, cRGD)-modified monomethoxy (polyethylene glycol)-poly (d,l-lactide-co-glycolide)-poly (l-lysine) nanoparticles (mPEG-PLGA-PLL-cRGD NPs) with antitumor drug Mitoxantrone (DHAQ) or fluorescence agent Rhodamine B (Rb) encapsulated in their interior were prepared. The remarkable features of the mPEG-PLGA-PLL-cRGD NPs are the effective improvement for the cytotoxicity and uptake of the cell in?vitro, and the significant enhancement of delivery ability for DHAQ or Rb in?vivo. As a consequence, an excellent therapeutic efficiency for cancer is obtained, demonstrating the mPEG-PLGA-PLL-cRGD NPs play a key role in enhancing cancer therapeutic efficiency.