- 作者：Ming-Lung Yu ; Chia-Yen Dai ; Chung-Feng Huang ; Jia-Jung Lee ; Ming-Lun Yeh ; Shih-Meng Yeh ; Hsing-Tao Kuo ; Jee-Fu Huang ; Jer-Ming Chang ; Hung-Chun Chen ; Suh-Hang Hank Juo ; Shang-Jyh Hwang ; Wan-Long Chuang ; FORMOSA-LIKE group
- 关键词：ALT ; alanine aminotransferase ; AST ; aspartate aminotransferase ; HBV ; hepatitis B virus ; HCV ; hepatitis C virus ; HBsAg ; hepatitis B surface antigen ; ESRD ; end-stage renal disease ; IL-28B ; interleukin 28B ; SNP ; single nucleotide polymorphism
- 刊名：Journal of Hepatology
- 出版年：February, 2014
- 年：2014
- 卷：60
- 期：2
- 页码：253-259
- 全文大小：838 K
Background & Aims
Host and viral factors interplay in the spontaneous clearance of hepatitis C virus (HCV) infection. We aimed to explore the roles of IL28B genotypes and hepatitis B virus (HBV) infections in spontaneous HCV seroclearance.Methods
IL28B rs8099917 genotypes, HCV and HBV markers were determined in 290 patients who were seropositive for HCV antibodies from 1681 total uremic patients on maintenance hemodialysis.
Results
Persistent HCV viremia was observed in 74.6% (214/287) of patients. Logistic regression revealed that the strongest factors associated with spontaneous HCV seroclearance were carriage of rs8099917 TT-type (odds ratio/95% confidence intervals [OR/CI]: 6.22/1.41-27.35, p = 0.016), followed by concurrent hepatitis B surface antigen (HBsAg) seropositivity (OR/CI: 2.37/1.06-5.26, p = 0.035). The clearance rate was highest among patients with both positive HBsAg/rs8099917 TT-type (44.8%, OR/CI: 20.88/3.5-402.5), followed by positive HBsAg/rs8099917 non-TT-type (28.6%, OR/CI: 8.86/1.8-160.8), and negative HBsAg/rs8099917 TT-type (26.7%, OR/CI: 12.75/1.0-319.4), compared to 4% of negative HBsAg/rs8099917 non-TT-type (trend p = 0.0002). HBsAg levels, but not HBV DNA levels, were significantly associated with spontaneous HCV seroclearance. Spontaneous HCV seroclearance rate was 58.3% in patients with HBsAg >200 IU/ml/rs8099917 TT-type (OR/CI: 42.54/5.7-908.4), 28.0% in patients with HBsAg <200 IU/ml/rs8099917 TT-type or HBsAg >200 IU/ml/rs8099917 non-TT-type (OR/CI: 11.12/2.3-201.0), compared to only 3.3% in those with HBsAg <200 IU/ml/rs8099917 non-TT-type (trend p = 0.0004). Five of 214 (2.3%) HCV viremic patients at enrollment had spontaneous HCV seroclearance during one-year follow-up, which was associated with baseline HCV RNA and HBsAg levels.
Conclusions
High HBsAg levels and favorable IL28B genotype were additively associated with spontaneous HCV seroclearance in uremic patients.