Further study on anti-inflammatory oxygenated steroids from the octocoral Dendronephthya griffini
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- 作者：Chih-Hua Chao ; Zhi-Hong Wen ; Jui-Hsin Su ; I-Ming Chen ; Ho-Cheng Huang ; Chang-Feng Dai ; Jyh-Horng Sheu
- 关键词：Dendronephthya griffini ; Anti-inflammatory ; Griffinisterones
- 刊名：Steroids
- 出版年：2008
- 出版时间：22 December 2008
- 年：2008
- 卷：73
- 期：14
- 页码：1353-1358
- 全文大小：466 K
文摘
Five new steroids, namely griffinisterones F–I (1–4) and griffinipregnone (5) have been isolated from the octocoral Dendronephthya griffini. The structures of these compounds were elucidated by extensive spectroscopic analysis. Compounds 1–3 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein of the LPS-stimulated RAW264.7 macrophage cells at 10 μM. At the same concentrations 2 also could significantly inhibit the accumulation of the pro-inflammatory COX-2 protein.