Systemic administration of the adenosine A_2A agonist CGS 21680 induces sedation at doses that suppress lever pressing and food intake

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• 作者：Susana Mingote ; Mariana Pereira ; Andrew M. Farrar ; Peter J. McLaughlin ; John D. Salamone
• 关键词：Motor ; Motivation ; Sleep ; Operant ; Basal Ganglia
• 刊名：Pharmacology Biochemistry and Behavior
• 出版年：2008
• 出版时间：May 2008
• 年：2008
• 卷：89
• 期：3
• 页码：345-351
• 全文大小：358 K

文摘

Adenosine A_2A receptors are involved in the regulation of several behavioral functions. Adenosine A_2A antagonists exert antiparkinsonian effects in animal models, and adenosine A_2A agonists suppress locomotion and impair various aspects of motor control. The present experiments were conducted to study the effects of low doses of the adenosine A_2A agonist CGS 21680 on lever pressing, specific parameters of food intake, and sedation. In the first experiment, the effects of CGS 21680 on fixed ratio 5 lever pressing were assessed. In the second experiment, rats were tested in 30 min feeding sessions, and also were observed for drug-induced sedation using a sedation rating scale. CGS 21680 (0.025, 0.05, 0.1 mg/kg IP) produced a dose related suppression of lever pressing, and also reduced the amount of food consumed. The feeding effect was largely dependent upon a slowing of the rate of feeding, and there was only a modest suppression of time spent feeding. Doses of CGS 21680 that suppressed lever pressing and feeding also were associated with sedation/drowsiness. In conjunction with other studies, the present results suggest that sedative effects may play an important role in some of the behavioral effects produced by systemic administration of adenosine A_2A agonists.