Dopamine/adenosine interactions related to locomotion and tremor in animal models: Possible relevance to parkinsonism
详细信息 查看全文
- 作者：John D. Salamone ; Keita Ishiwari ; Adrienne J. Betz ; Andrew M. Farrar ; Susana M. Mingote ; Laura Font ; Jö ; rg Hockemeyer ; Christa E. Mü ; ller ; Mercè ; Correa
- 关键词：Dopamine ; Basal ganglia ; Neostriatum ; Caudate ; Putamen ; Nucleus accumbens ; Antipsychotic ; Parkinson's disease ; Motor ; Motivation
- 刊名：Parkinsonism and Related Disorders
- 出版年：2008
- 出版时间：July 2008
- 年：2008
- 卷：14
- 期：Supplement 2
- 页码：S130-S134
- 全文大小：133 K
文摘
Adenosine A2A antagonists can exert antiparkinsonian effects in animal models. Recent experiments studied the ability of MSX-3 (an adenosine A2A antagonist) to reverse the locomotor suppression and tremor produced by dopamine antagonists in rats. MSX-3 reversed haloperidol-induced suppression of locomotion, and reduced the tremulous jaw movements induced by haloperidol, pimozide, and reserpine. Infusions of MSX-3 into the nucleus accumbens core increased locomotion in haloperidol-treated rats, but there were no effects of infusions into the accumbens shell or ventrolateral neostriatum. In contrast, MSX-3 injected into the ventrolateral neostriatum reduced pimozide-induced tremulous jaw movements. Dopamine/adenosine interactions in different striatal subregions are involved in distinct aspects of motor function.