Oral administration with attenuated Salmonella encoding a Trichinella cystatin-like protein elicited host immunity
详细信息 查看全文
- 作者：X.D Liua ; 1 ; X.L. Wanga ; 1 ; X. Baia ; 1 ; X.L. Liua ; 1 ; X.P. Wub ; xpwu@jlu.edu.cn" class="auth_mail ; Y. Zhaoa ; zhaoyingsohu@sohu.com" class="auth_mail ; S.M. Suna ; L. Yua ; X.Z. Sud ; Z.Q. Wange ; F. Wanga ; M.Y. Liua ; c ; liumy@jlu.edu.cn" class="auth_mail ; mingyuanliu16@aliyun.com" class="auth_mail
- 关键词：Trichinella spiralis ; Cystatin-like protein ; Attenuated Salmonella ; Th1/Th2 ; Immunosuppressive ; Eukaryotic expression system
- 刊名：Experimental Parasitology
- 出版年：June 2014
- 年：2014
- 卷：141
- 期：Complete
- 页码：1-11
- 全文大小：2913 K
文摘
- •
A eukaryotic expression system was used to ensure the similarity of the expressed protein and the native protein.
- •
The recombinant Salmonella invasion process was similar to the natural course of infection with Trichinella.
- •
Th1- and Th2-specific cellular transcription factors and the cytokine profile were evaluated.
- •
T lymphocytes and macrophages were detected by flow cytometry.