MiR-203 suppresses tumor growth and invasion and down-regulates MiR-21 expression through repressing Ran in esophageal cancer

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• 作者：Fang Zhang ; Zhiping Yang ; Minjun Cao ; Yinsheng Xu ; Jintao Li ; Xuebin Chen ; Zhi Gao ; Jing Xin ; Shaomei Zhou ; Zhixiang Zhou ; Yishu Yang ; Wang Sheng ; Yi Zeng
• 关键词：Esophageal cancer ; MiR-203 ; MiR-21 ; Ran ; Tumor suppressor
• 刊名：Cancer Letters
• 出版年：1 January, 2014
• 年：2014
• 卷：342
• 期：1
• 页码：121-129
• 全文大小：1655 K

文摘

The expression of miR-203 has been reported to be significantly down-regulated in esophageal cancer. We showed here that overexpression of miR-203 in esophageal cancer cells dramatically increased cell apoptosis and inhibited cell proliferation, migration and invasion as well as tumor growth and down-regulated miR-21 expression. We subsequently identified that small GTPase Ran was a target gene of miR-203. Furthermore, Ran restoration partially counteracted the tumor suppressive effects of miR-203 and increased miR-21 expression. Taken together, our findings suggest that miR-203 may act as novel tumor suppressor in esophageal cancer through down-regulating the expression of Ran and miR-21.