The biliprotein C-phycocyanin modulates the early radiation response: A pilot study
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- 作者：Katia G. Ivanova ; Katia G. Stankova ; Vladimir N. Nikolov ; Radostina T. Georgieva ; Kaledona M. Minkova ; Lili G. Gigova ; Ivanka T. Rupova ; Rayna N. Boteva
- 关键词：Antioxidants ; ROS ; Low-dose radiation ; C-phycocyanin ; Manganese super oxide dismutase (MnSOD) ; Catalase ; Glutathione-S-transferase (GST) ; Occupational exposure
- 刊名：Mutation Research/Genetic Toxicology and Environmental Mutagenesis
- 出版年：2010
- 出版时间：January 2010
- 年：2010
- 卷：695
- 期：1-2
- 页码：40-45
- 全文大小：325 K
文摘
This study analyzed the effects of biliprotein C-phycocyanin (C-PC) on the enzymatic antioxidant defence system in lymphocytes of nuclear power-plant workers and non-exposed controls. Changes in the protein levels of manganese super oxide dismutase (MnSOD), catalase and glutathione-S-transferase (GST) were used as markers for early biological effects of a single in vitro exposure of cells to: (i) 2 Gy gamma rays; (ii) 5 μM C-PC; and (iii) a combination of C-PC plus irradiation with 2 Gy. The results showed that C-PC selectively stimulated the lymphocyte antioxidant defence system of occupationally exposed subjects. The activation of the antioxidant protective mechanisms as part of the early radiation response was probably related to the chronic low-dose occupational exposure. The modulating capacity of C-PC at the molecular level may be of interest for the protection of occupationally exposed persons.