Effects of protostane-type triterpenoids on the 5-HT3A receptor-mediated ion current in Xenopus oocytes
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- 作者：Jun-Ho Lee ; Yoo-Jin Lee ; Seok-Woo Kang ; Yangseok Kim ; Minkyu Shin ; Moochang Hong ; Eun-Kyoung Seo ; Sung-Hoon Kim ; Seung-Yeol Nah ; Hyunsu Bae
- 关键词：Triterpenoid ; 5-HT3A receptor ; Two-electrode voltage clamp
- 刊名：Brain Research
- 出版年：2010
- 出版时间：17 May 2010
- 年：2010
- 卷：1331
- 期：Complete
- 页码：20-27
- 全文大小：634 K
文摘
Alisol derivatives are unique protostane-type triterpenoid compounds that are isolated from Alismatis rhizoma, which is a well-known traditional medicine in East Asia. In the present study, we investigated the effects of protostane-type triterpenoids (AA, Alisol A; AB, Alisol B; AB-ac, Alisol B 23-acetate; AC-ac, Alisol C 23-aceteate) on 5-HT-induced currents mediated by the human 5-HT3A receptor expressed in Xenopus laevis oocytes. Co-treatment with triterpenoids regulated the 5-HT-induced inward peak current in a concentration-dependent and reversible manner. In addition, regulation of I5-HT by triterpenoids occurred in a non-competitive manner. Taken together, these results indicate that triterpenoids may regulate the 5-HT3A receptors that are expressed in Xenopus oocytes. Furthermore, this regulation of the ligand-gated ion channel activity by triterpenoids may be one of the pharmacological actions of Alismatis rhizoma.