MicroRNA-187-3p mitigates non-small cell lung cancer (NSCLC) development through down-regulation of BCL6

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• 作者：Chengcao Sun^a ; Shujun Li^a ; ^b ; Cuili Yang^a ; Yongyong Xi^a ; Liang Wang^a ; Feng Zhang^a ; Dejia Li^a ; ^{lodjlwhu@sina.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Hsa-miRNA-187-3p (miR-187-3p) ; BCL6 ; Non-small cell lung cancer (NSCLC) ; Proliferation ; Apoptosis
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2016
• 出版时间：26 February 2016
• 年：2016
• 卷：471
• 期：1
• 页码：82-88
• 全文大小：1498 K

文摘

Hsa-microRNA-187-3p (miR-187-3p) has recently been discovered having anticancer efficacy in different organs. However, the role of miR-187-3p on non-small cell lung cancer (NSCLC) is still ambiguous. In this study, we investigated the role of miR-187-3p on the development of NSCLC. The results indicated that miR-187-3p was significantly down-regulated in primary tumor tissues and very low levels were found in NSCLC cell lines. Ectopic expression of miR-187-3p in NSCLC cell lines significantly suppressed cell growth as evidenced by cell viability assay and colony formation assay, through inhibition of BCL6. In addition, miR-187-3p induced apoptosis, as indicated by concomitantly with up-regulation of the activities of caspase-3 and caspase-7, and inhibited cellular migration and invasiveness through inhibition of BCL6. Further, oncogene BCL6 was revealed to be a putative target of miR-187-3p, which was inversely correlated with miR-187-3p expression in NSCLC. Taken together, our results demonstrated that miR-187-3p played a pivotal role on NSCLC through inhibiting cell proliferation, migration, invasion, and promoting apoptosis by targeting oncogenic BCL6.