miR-187-3p inhibits the metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by targeting S100A4
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- 作者：Changwei Dou ; Zhikui Liu ; Meng Xu ; Yuli Jia ; Yufeng Wang ; Qing Li ; Wei Yang ; Xin Zheng ; Kangsheng Tu ; tks0912@foxmail.com" class="auth_mail" title="E-mail the corresponding author ; Qingguang Liu ; dcwtmac@sina.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：miR-187-3p ; S100A4 ; Hepatocellular carcinoma ; Metastasis ; EMT
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 October 2016
- 年：2016
- 卷：381
- 期：2
- 页码：380-390
- 全文大小：5320 K
文摘
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miR-187-3p is significantly down-regulated in HCC, and is correlated with adverse clinical features and poor prognosis of HCC patients.
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miR-187-3p can inhibit the metastasis of HCC cells by regulating EMT phenotype.
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S100A4 is a direct downstream target of miR-187-3p, and mediated the biological function of miR-187-3p in HCC.
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miR-187-3p is down-regulated by hypoxia, and is involved in the metastasis and EMT of HCC cells promoted by hypoxia.