MicroRNA-187-5p suppresses cancer cell progression in non-small cell lung cancer (NSCLC) through down-regulation of CYP1B1

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• 作者：Ming Mao ; Zhouqing Wu ; Jiakuan Chen ; ^{jiakuanchen027@sina.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：hsa-miRNA-187-5p (miR-187-5p) ; CYP1B1 ; Non-small cell lung cancer (NSCLC) ; Proliferation ; Apoptosis
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2016
• 出版时间：16 September 2016
• 年：2016
• 卷：478
• 期：2
• 页码：649-655
• 全文大小：1468 K

文摘

Lung cancer remains a leading cause of cancer-associated mortality worldwide and non-small lung cancer (NSCLC) is responsible for over 80% of lung cancer-related deaths. Identifying novel molecular biomarker that can inhibit the progression of lung cancer will facilitate the development of new treatment strategies. Herein, we demonstrated that miR-187-5p is a tumor-suppressor miRNA in NSCLC progression. We found that expression of miR-187-5p was decreased obviously in NSCLC tissues. Down-regulation of miR-187-5p was associated with TNM stage and postoperative survival. Overexpression of miR-187-5p inhibited the growth and metastasis of NSCLC cells. The CYP1B1 was a direct target of miR-187-5p and promoted the growth and metastasis of NSCLC cells. Further study showed that CYP1B1 could reverse the inhibitory effect of miR-187-5p on growth and metastasis of NSCLC cells. Taken together, our data highlight the pivotal role of miR-187-5p in the progression of NSCLC. Thus, miR-187-5p may be a potential prognostic marker and of treatment relevance for NSCLC progression intervention.