miR-137 suppresses tumor growth of malignant melanoma by targeting aurora kinase A
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- 作者：Xiao Changa ; Haiping Zhanga ; Shi Lianb ; Wei Zhua ; zhuwei_2020@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：miR-137 ; Malignant melanoma ; Aurora kinase A ; Cell growth
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：475
- 期：3
- 页码：251-256
- 全文大小：1986 K
文摘
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First reported overexpression of AURKA in melanoma.
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Targeting AURKA inhibits melanoma growth in vitro and in vivo.
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Further found miR-137 suppressed cell growth by binding to AURKA 3′UTR.
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Re-expression of AURKA rescued miR-137-mediated suppression.
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miR-137-AURKA axis may be potential therapeutic targets of melanoma.