miR-430 regulates oriented cell division during neural tube development in zebrafish
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- 作者：Carter M. Takacsa ; carter.takacs@yale.edu" class="auth_mail" title="E-mail the corresponding author ; Antonio J. Giraldeza ; b ; antonio.giraldez@yale.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：MicroRNAs ; Zebrafish ; Neural tube
- 刊名：Developmental Biology
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：409
- 期：2
- 页码：442-450
- 全文大小：6263 K
文摘
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Loss of miR-430 function leads to accumulation of ectopic progenitors in the dorsal neural tube.
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Daughter cells fail to distribute across the axial midline.
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Neural defects are associated with misoriented neural keel cell divisions.
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Misregulated genes in neuroectoderm are enriched for miR-430 target sequences.