Microtubule-Dependent Mitochondria Alignment Regulates Calcium Release in Response to Nanomechanical Stimulus in Heart Myocytes
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- 作者：Michele Miragoli1 ; 2 ; 3 ; michele.miragoli@humanitasresearch.it" class="auth_mail" title="E-mail the corresponding author ; Jose L. Sanchez-Alonso1 ; Anamika Bhargava1 ; 6 ; Peter T. Wright1 ; Markus Sikkel1 ; Sophie Schobesberger1 ; Ivan Diakonov1 ; Pavel Novak1 ; 5 ; Alessandra Castaldi2 ; Paola Cattaneo2 ; Alexander R. Lyon1 ; 4 ; Max J. Lab1 ; m.lab@imperial.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Julia Gorelik1 ; j.gorelik@imperial.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：5 January 2016
- 年：2016
- 卷：14
- 期：1
- 页码：140-151
- 全文大小：3637 K
文摘
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Nanomechanical pressure application changes mechanosensitivity in failing heart cells
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Microtubular network disorganization mediates the change in mechanosensitivity
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Mitochondria are displaced from their original location and trigger calcium release
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Uncoupling the mitochondrial proton gradient completely abolishes the phenomena