Nanotechnologies for biomolecular detection and medical diagnostics
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- 作者：Mark Ming-Cheng Cheng ; Giovanni Cuda ; Yuri L Bunimovich ; Marco Gaspari ; James R Heath ; Haley D Hill ; Chad A Mirkin ; A Jasper Nijdam ; Rosa Terracciano ; Thomas Thundat and Mauro Ferrari
- 刊名：Current Opinion in Chemical Biology
- 出版年：2006
- 出版时间：February 2006
- 年：2006
- 卷：10
- 期：1
- 页码：11-19
- 全文大小：640 K
文摘
Nanotechnology-based platforms for the high-throughput, multiplexed detection of proteins and nucleic acids in heretofore unattainable abundance ranges promise to bring substantial advances in molecular medicine. The emerging approaches reviewed in this article, with reference to their diagnostic potential, include nanotextured surfaces for proteomics, a two-particle sandwich assay for the biological amplification of low-concentration biomolecular signals, and silicon-based nanostructures for the transduction of molecular binding into electrical and mechanical signals, respectively.