Cervical leukocytes and spontaneous preterm birth
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- 作者：Patricia J. Huntera ; patricia.hunter@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Sairah Sheikha ; c ; Anna L. Davidb ; Donald M. Peeblesb ; Nigel Kleina
- 关键词：SPTB ; spontaneous preterm birth ; LMC ; late miscarriage ; PMN ; polymorphonuclear cells
- 刊名：Journal of Reproductive Immunology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：113
- 期：Complete
- 页码：42-49
- 全文大小：1342 K
文摘
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Hypothesis that defects in cervical immunity might be a feature of spontaneous preterm birth (SPTB).
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A prospective observational study of 120 pregnancies at risk of SPTB because of the mother’s history.
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Cervical leukocytes, cytokines and chemokines were sampled at 12–25 weeks using a cytobrush.
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Early SPTB (<34 weeks) lacked cervical macrophages and had low CCL2 (<75 ng/g total protein).