Levels of thrombin-activatable fibrinolysis inhibitor and platelet-activating factor in recurrent pregnancy loss patients

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• 作者：Ayla Eser^a ; ^{aylaacar76@yahoo.com.tr" class="auth_mail" title="E-mail the corresponding author} ; Ilknur Inegol Gumus^a ; Husamettin Erdamar^b ; Ikbal Kaygusuz^a ; Melahat Yildirim^c ; Betul Usluogullari^d ; Muzeyyen Duran Erdolu^e ; Serap Aynur Simavli^f ; Ramazan Yigitoglu^b ; Nilgun Ozturk Turhan^g
• 关键词：abortion ; habitual ; carboxypeptidase B2 ; platelet activating factor ; pregnancy
• 刊名：Taiwanese Journal of Obstetrics and Gynecology
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：55
• 期：1
• 页码：60-63
• 全文大小：220 K

文摘

The aim of this study was to investigate factors associated with thrombosis that may contribute to recurrent pregnancy loss (habitual abortion), specifically differences in serum levels of platelet-activating factor and thrombin-activatable fibrinolysis inhibitor (carboxypeptidase B2) between women with a history of recurrent miscarriage and those with no recurrent miscarriage history.

Materials and methods

A case-controlled, prospective study design was adopted to compare women with a history of two or more first-trimester miscarriages (n = 42) with those with no history of recurrent miscarriage (n = 36). Participants were recruited from the Department of Obstetrics and Gynecology of Turgut Ozal University Hospital. Platelet-activating factor and thrombin-activatable fibrinolysis inhibitor levels in serum samples were measured by an enzyme-linked immunosorbent assay.

Results

Platelet-activating factor levels were significantly (p = 0.018) higher in the recurrent miscarriage group. There was no difference in levels of thrombin-activatable fibrinolysis inhibitor expression between the groups.

Conclusion

Platelet-activating factor is significantly higher in serum of patients with a history of recurrent miscarriage than in those without such a history, with potential implications for placental function and fetal growth, which could be relevant to miscarriage recurrence. Larger studies are indicated to further examine these findings.