EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling
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- 作者：Feng Liu1 ; 11 ; Gary C. Hon1 ; 10 ; 11 ; Genaro R. Villa1 ; 6 ; Kristen M. Turner1 ; Shiro Ikegami1 ; Huijun Yang1 ; Zhen Ye1 ; Bin Li1 ; Samantha Kuan1 ; Ah Young Lee1 ; Ciro Zanca1 ; Bowen Wei6 ; Greg Lucey6 ; David Jenkins1 ; Wei Zhang7 ; Cathy L. Barr8 ; 9 ; Frank B. Furnari1 ; 2 ; Timothy F. Cloughesy6 ; William H. Yong6 ; Timothy C. Gahman1 ; Andrew K. Shiau1 ; Webster K. Cavenee1 ; 3 ; 5 ; Bing Ren1 ; 4 ; 5 ; biren@ucsd.edu" class="auth_mail" title="E-mail the corresponding author ; Paul S. Mischel1 ; 2 ; 5 ; pmischel@ucsd.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2015
- 出版时间：15 October 2015
- 年：2015
- 卷：60
- 期：2
- 页码：307-318
- 全文大小：2611 K
文摘
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Oncogenic EGFRvIII mutation remodels the enhancer landscape in GBM
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EGFRvIII induces SOX9 and FOXG1 transcription in GBM
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SOX9 and FOXG1 collaborate to activate an oncogenic gene regulatory program
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EGFRvIII-dependent transcription sensitizes GBM cells to JQ1