PZP and PAI-2: Structurally-diverse, functionally similar pregnancy proteins?

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• 作者：Amy R. Wyatt^a ; ^b ; Jordan H. Cater^a ; ^b ; Marie Ranson^a ; ^b ; ^{mranson@uow.edu.au" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Pregnancy zone protein ; Plasminogen activator inhibitor type 2/SERPINB2 ; Preeclampsia ; Protein misfolding
• 刊名：International Journal of Biochemistry and Cell Biology
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：79
• 期：Complete
• 页码：113-117
• 全文大小：974 K

文摘

Pregnancy zone protein (PZP) and plasminogen activator inhibitor type 2 (PAI-2) are two multifunctional proteins that are elevated in normal pregnancy and numerous other inflammatory states. Both proteins were originally identified as protease inhibitors, but current evidence supports the notion that they may also function as modulators of T-helper cells and/or extracellular chaperones. Exacerbated inflammation, fibrinolytic disturbances and misfolded proteins are all implicated in the pathology of preeclampsia, a leading cause of maternal and foetal mortality and morbidity. Notably, reduced levels of PZP or PAI-2 are associated with preeclampsia and clarification of their diverse functions in normal pregnancy could provide much needed insight regarding the pathogenesis of this disorder. Given that inflammation and protein misfolding underlie the pathology of a very large number of disorders, the contributions of PZP and PAI-2 to extracellular proteostasis and immunoregulation could be broad-reaching.